The series follows Paige and Frankie who write funny songs and create music comedy videos for their online channel, Bizaardvark. Now with 10,000 subscribers, they are invited to produce their videos at the influential Vuuugle Studios. In this cool environment – and with the help of longtime friend and 12-year-old agent Bernie, plus fellow Vuuugle stars Dirk (of "Dare Me Bro!") and Amelia (of "Perfect Perfection with Amelia") – the best friends embark on comedic adventures in their quest to rule the blogosphere.
The series revolves around two 12-year-old best friends, Paige and Frankie, who write funny songs and create music videos for their online channel, titled Bizaardvark, which has 10,000 subscribers. The amateur musicians get to work from a creative studio space that they hope will take their videos to the next level. In their cool new environment, and with the help of family and friends, the girls will embark on a series of comedic adventures in their quest to become online stars.